Peripheral neurology of the diabetic Chinese hamster

Genetically diabetic Chinese hamsters were examined anatomically and physiologically for evidence of peripheral neuropathy. Control animals were from non-diabetic strains. Conduction velocities in both motor and sensory components of the hind limb nerves were reduced 16-22% in diabetic compared with control hamsters. However, there was no reduction in nerve fibre diameters or other signs of abnormal morphology that could be correlated with these physiological effects. It is concluded that the diabetic hamster is useful as a model of human diabetic peripheral neuropathy, but the analogy is not precise. The neuropathy of moderately diabetic hamsters is generally less severe than human diabetic neuropathy in its clinical stages.