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Cardiopulmonary bypass-induced complement activation. Evidence for C5a participation
The International Journal of Artificial Organs
|September 1, 1982
Summary
During cardiopulmonary bypass, plasma activities increased, leading to polymorphonuclear neutrophils (PMN) aggregation and adherence. These changes correlated with a drop in circulating PMN counts, impacting immune response.
Area of Science:
- Cardiovascular Surgery
- Immunology
- Hematology
Background:
- Cardiopulmonary bypass (CPB) is associated with inflammatory responses.
- Polymorphonuclear neutrophils (PMN) play a key role in the inflammatory cascade during CPB.
Purpose of the Study:
- To investigate plasma activities affecting PMN during cardiopulmonary bypass.
- To correlate these activities with peripheral PMN counts.
Main Methods:
- Measurement of plasma activities inducing PMN aggregation and adherence.
- Assessment of plasma chemotactic activity.
- Monitoring of peripheral PMN counts in patients undergoing CPB.
Main Results:
- Plasma chemotactic activity and PMN aggregation-inducing activity were detected during CPB.
- Peak levels of these activities preceded a significant decrease in peripheral PMN count.
- Increased PMN adherence activity, when observed, preceded the maximum of other evaluated activities.
Conclusions:
- CPB triggers plasma-mediated PMN activation and migration.
- The observed changes in PMN activity and count suggest a complex immune response during CPB.
- Understanding these dynamics is crucial for managing CPB-related complications.