Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myopathy in the nyala

S Liu, E P Dolensek, A J Herron

    Journal of the American Veterinary Medical Association
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    International round-robin experiment for angle-resolved light scattering measurement.

    Applied optics·2019
    Same author

    Forecasting the global demand for HIV monitoring and diagnostic tests: A 2016-2021 analysis.

    PloS one·2018
    Same author

    Swine as models in biomedical research and toxicology testing.

    Veterinary pathology·2011
    Same author

    The Spectrum projection package: improvements in estimating incidence by age and sex, mother-to-child transmission, HIV progression in children and double orphans.

    Sexually transmitted infections·2010
    Same author

    The Spectrum projection package: improvements in estimating mortality, ART needs, PMTCT impact and uncertainty bounds.

    Sexually transmitted infections·2008
    Same author

    Projecting the demographic impact of AIDS and the number of people in need of treatment: updates to the Spectrum projection package.

    Sexually transmitted infections·2006

    Myopathy caused the deaths of 21 nyalas (Tragelaphus angasi). Low plasma alpha tocopherol (vitamin E) levels were observed in affected animals, suggesting a potential nutritional deficiency contributing to the disease.

    Area of Science:

    • Veterinary Pathology
    • Animal Nutrition
    • Wildlife Diseases

    Background:

    • Myopathy, a disease affecting muscle tissue, has been observed in nyalas (Tragelaphus angasi).
    • Clinical signs include stiffness, recumbency, and failure to suckle in neonates, often with sudden death.
    • Gross lesions involve characteristic white or pale patches in skeletal and cardiac muscle.

    Purpose of the Study:

    • To investigate the clinical and pathological findings associated with myopathy in nyalas.
    • To evaluate the role of plasma alpha tocopherol (vitamin E) and blood selenium levels in affected nyalas.

    Main Methods:

    • Retrospective analysis of 21 nyala cases with myopathy from January 1973 to June 1981.
    • Clinical and pathological data collection, including gross and histological examination of muscle tissues.

    Related Experiment Videos

  • Biochemical analysis of plasma alpha tocopherol and blood selenium levels in affected and unaffected nyalas.

    • Main Results:

    • Histological findings revealed acute degeneration, necrosis, and mineralization in skeletal muscle, and myocardial necrosis in juveniles.
    • Adult nyalas commonly exhibited myocardial interstitial fibrosis and arteriosclerosis.
    • Affected nyalas had significantly lower plasma alpha tocopherol levels (mean 0.05 mg/dl) compared to unaffected animals (mean 0.13 mg/dl), indicating deficiency.
    • Blood selenium levels were within normal ranges for all examined nyalas.

    Conclusions:

    • Myopathy in nyalas is characterized by significant muscle degeneration and necrosis.
    • Low plasma alpha tocopherol levels suggest a potential link between vitamin E deficiency and the development of myopathy in this species.
    • Further research into nutritional management and vitamin E supplementation may be warranted for affected nyala populations.