Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrically enhanced osteogenesis at various metal cathodes

J A Spadaro

    Journal of Biomedical Materials Research
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Muscle indices do not fully account for enhanced upper extremity bone mass and strength in gymnasts.

    Journal of musculoskeletal & neuronal interactions·2009
    Same author

    Density and structural changes in the bone of growing rats after weekly alendronate administration with and without a methotrexate challenge.

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2006
    Same author

    Novel radioprotectant drugs for sparing radiation-induced damage to the physis.

    International journal of radiation biology·2004
    Same author

    In vivo and in vitro effects of a pulsed electromagnetic field on net calcium flux in rat calvarial bone.

    Calcified tissue international·2002
    Same author

    Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone.

    International journal of radiation oncology, biology, physics·2001
    Same author

    Sparing of radiation-induced damage to the physis: fractionation alone compared to amifostine pretreatment.

    International journal of radiation oncology, biology, physics·2000

    Metallic cathodes stimulated bone growth in rabbit medullary canals. Different metals and current densities influenced new bone formation, suggesting an electrochemical mechanism for osteogenesis.

    Area of Science:

    • Biomaterials Science
    • Orthopedic Research
    • Electrophysiology

    Background:

    • Investigating methods to enhance bone regeneration is crucial for orthopedic applications.
    • Electrode stimulation is a potential therapeutic approach for bone repair.

    Purpose of the Study:

    • To evaluate the effect of different metallic cathode materials on electrode-induced bone formation.
    • To determine the influence of varying current densities on osteogenesis.
    • To explore the underlying mechanisms of electrode-stimulated bone growth.

    Main Methods:

    • Six metallic cathode materials were tested in the rabbit medullary canal.
    • Direct cathodic currents (0.02 and 0.2 microA/mm2) were applied for 21 days.
    • Quantitative analysis of new bone growth and vascular channels was performed.

    Related Experiment Videos

    Main Results:

    • Significant increases in new bone formation (46-48%) were observed with active electrodes compared to controls.
    • Material-specific differences in bone growth were noted, with platinum, cobalt-chrome, and silver performing better at lower currents, and stainless steel and titanium at higher currents.
    • No significant differences in vascular channel formation were found within the 21-day study period.
    • Platinum showed the most stimulation at control (non-current) levels, indicating inherent material effects.

    Conclusions:

    • Electrode stimulation significantly enhances bone formation in the medullary canal.
    • The effectiveness of different cathode materials and current densities varies, suggesting an electrochemical mechanism.
    • Further research into interfacial electrochemical processes is warranted to optimize electrode-stimulated osteogenesis.