GLC determination of phenacemide in tablets

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis

Background:

• Phenacemide is an anticonvulsant medication.
• Accurate quantification of phenacemide in pharmaceutical formulations is crucial for therapeutic efficacy and patient safety.
• Existing analytical methods may be time-consuming or lack optimal efficiency.

Purpose of the Study:

• To develop and validate a gas-liquid chromatography (GLC) procedure for the accurate and efficient determination of phenacemide.
• To compare the developed GLC method with the official assay in terms of time consumption and accuracy.

Main Methods:

• Development of a gas-liquid chromatography (GLC) method for phenacemide.
• Extraction of phenacemide from powdered tablet formulations.
• Utilized pentylenetetrazol as the internal standard.
• Quantification by comparing the ratio of peak areas of phenacemide to the internal standard against a reference standard.

Main Results:

• The developed GLC procedure provides accurate quantification of phenacemide.
• The new method is significantly less time-consuming compared to the official assay.
• Accuracy was maintained without compromise, demonstrating the reliability of the GLC technique.

Conclusions:

• The developed gas-liquid chromatography (GLC) procedure offers a more efficient and accurate alternative for phenacemide analysis in pharmaceutical preparations.
• This method streamlines the analytical process without sacrificing the precision required for quality control.