Enuresis treatment with imipramine hydrochloride: a 10-year follow-up study

The authors followed 29 young adults who had been treated for enuresis with imipramine hydrochloride 10 years earlier. To test beliefs that enuresis is symptomatic of severe psychopathology or of urological conditions, they studied whether the treatment had been followed by psychological decompensation; an inhibition of learning; a predisposition to drug abuse; negative effects on health, growth, weight, and development; or continued urinary symptoms. None of these negative effects was present; in general the subjects were active, well-motivated, and sociable and showed no significant psychiatric symptoms. One patient still wetted but only occasionally.