Combined paraquat and acetaminophen toxicity

A case of combined paraquat and acetaminophen ingestion is reported with accompanying serial serum levels (including pre- and postcharcoal hemoperfusion) and autopsy tissue levels of both toxins. An increased lethality (time until death) is suggested in rats receiving both toxins as compared to either toxin alone. A proposed mechanism for the combined toxicity of the two drugs is hypothesized.