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Disopyramide fatality: case report and GC/FID analysis

R W Michalek, T A Rejent, R A Spencer

    Journal of Analytical Toxicology
    |September 1, 1982
    PubMed
    Summary
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    A massive disopyramide overdose in a young male resulted in death, with blood levels 15 times higher than therapeutic. Gas chromatography with flame ionization detection confirmed the high drug concentration.

    Area of Science:

    • Forensic toxicology
    • Analytical chemistry
    • Pharmacology

    Background:

    • Disopyramide is an antiarrhythmic medication.
    • Drug overdose cases require accurate quantitation for toxicological analysis.
    • Massive ingestion can lead to fatal outcomes without medical intervention.

    Observation:

    • A 19-year-old male was found deceased following a suspected massive ingestion of disopyramide.
    • No medical intervention was administered prior to death.
    • Toxicological analysis was performed on biological samples.

    Findings:

    • Disopyramide was identified using thin-layer chromatography (TLC) and ultraviolet spectrophotometry (UVS).
    • Quantitation of disopyramide was achieved via gas chromatography with a flame ionization detector (GC/FID).

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  • Blood disopyramide concentration was found to be 15 times the typical therapeutic level.

    • Implications:

    • This case highlights the lethal potential of massive disopyramide overdose.
    • Accurate toxicological methods like GC/FID are crucial for confirming high drug concentrations in forensic investigations.
    • Understanding drug quantitation is vital for determining cause of death in overdose cases.