The use of isotope effects to determine transition-state structure for enzymic reactions

pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).

FEBS letters·2013

Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli.

Biochemistry·2013

Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses.

Biochemistry·2012

A kinetic and isotope effect investigation of the urease-catalyzed hydrolysis of hydroxyurea.

Biochemistry·2010

13C isotope effect on the reaction catalyzed by prephenate dehydratase.

Biochimica et biophysica acta·2009

A heavy-atom isotope effect and kinetic investigation of the hydrolysis of semicarbazide by urease from jack bean (Canavalia ensiformis).

Biochemistry·2008

Mechanistic insights on HDAC6 ZnF UBP-Tau interaction through biophysical and computational approaches.

Methods in enzymology·2026

Methodological frameworks to probe histone acetylation-driven circuit plasticity in SYNGAP1-associated neurodevelopmental disorders.

Methods in enzymology·2026

Methodological approach to investigate peroxiredoxin 1 deacetylation by histone deacetylase 6.

Methods in enzymology·2026

Protocols for in vitro analysis of liquid-liquid phase separation of proteins.

Methods in enzymology·2026

Experimental approaches to study histone deacetylation in Caenorhabditis elegans.

Methods in enzymology·2026

Histone deacetylases: From acetylation homeostasis to oncogenic and neurodegenerative disorders.

Methods in enzymology·2026

Photothermal CO2 hydrogenation for C1 fuels: fundamentals, reaction pathways and reactor design.

Chemical communications (Cambridge, England)·2026

From electromagnetic field-material interactions to intensified chemical manufacturing via microwave catalysis.

Chemical Society reviews·2026

Enhanced methane selectivity by electrochemical CO2 reduction at a choline-alaninate/Au(111) interface: DFT and microkinetic insights.

Physical chemistry chemical physics : PCCP·2026

Biomimetic spatial compartmentalization directs C1 intermediate evolution for highly selective CO2 photomethanation.

Chemical science·2026

A Stereoconvergent Annulation in the Synthesis of Lysergic Acid.

Synthesis·2026

Space-velocity-governed chemoselective pseudo-oxidation: a convergent flow platform for the synthesis of evocalcet.

RSC advances·2026

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The use of isotope effects to determine transition-state structure for enzymic reactions

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pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).

Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli.

Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses.

A kinetic and isotope effect investigation of the urease-catalyzed hydrolysis of hydroxyurea.

13C isotope effect on the reaction catalyzed by prephenate dehydratase.

A heavy-atom isotope effect and kinetic investigation of the hydrolysis of semicarbazide by urease from jack bean (Canavalia ensiformis).

Mechanistic insights on HDAC6 ZnF UBP-Tau interaction through biophysical and computational approaches.

Methodological frameworks to probe histone acetylation-driven circuit plasticity in SYNGAP1-associated neurodevelopmental disorders.

Methodological approach to investigate peroxiredoxin 1 deacetylation by histone deacetylase 6.

Protocols for in vitro analysis of liquid-liquid phase separation of proteins.

Experimental approaches to study histone deacetylation in Caenorhabditis elegans.

Histone deacetylases: From acetylation homeostasis to oncogenic and neurodegenerative disorders.

Photothermal CO2 hydrogenation for C1 fuels: fundamentals, reaction pathways and reactor design.

From electromagnetic field-material interactions to intensified chemical manufacturing via microwave catalysis.

Enhanced methane selectivity by electrochemical CO2 reduction at a choline-alaninate/Au(111) interface: DFT and microkinetic insights.

Biomimetic spatial compartmentalization directs C1 intermediate evolution for highly selective CO2 photomethanation.

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The use of isotope effects to determine transition-state structure for enzymic reactions

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