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Metkephamid effects on operant behavior

J D Leander, C R Wood

    Peptides
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Metkephamid

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    Area of Science:

    • Behavioral pharmacology
    • Neuroscience
    • Opioid receptor research

    Background:

    • Metkephamid is a compound with potential opioid receptor activity.
    • Understanding its behavioral effects is crucial for pharmacological research.

    Purpose of the Study:

    • To investigate the behavioral effects of metkephamid in pigeons.
    • To determine the involvement of mu-opioid receptors in metkephamid's action.
    • To examine potential interactions with other opioids like d-methadone.

    Main Methods:

    • Pigeons were trained on a multiple fixed-ratio, fixed-interval schedule.
    • Intravenous injections of metkephamid were administered at high doses.
    • Naloxone was used to assess antagonism of metkephamid's effects.

    Related Experiment Videos

  • Daily oral administration of d-methadone was employed to study interactions.

    • Main Results:

    • High doses of metkephamid (20 and 40 mg/kg IV) significantly decreased pigeon responding.
    • Naloxone dose-dependently reversed the behavioral suppression caused by metkephamid.
    • Chronic d-methadone administration caused a rightward shift in the metkephamid dose-effect curve.

    Conclusions:

    • Metkephamid's behavioral effects are mediated through the mu-opioid receptor.
    • These findings support the hypothesis of metkephamid acting as a mu-opioid agonist.
    • The study provides evidence for opioid receptor interactions.