Related Experiment Videos
[IgD level in healthy children of various age]
Problemy Medycyny Wieku Rozwojowego
|January 1, 1982
Insights
Immunoglobulin D (IgD) is not detected in newborns or infants. IgD levels become detectable after one year, with average levels remaining stable in older children.
Area of Science:
- Immunology
- Pediatrics
- Clinical Chemistry
Background:
- Immunoglobulin D (IgD) is a crucial antibody isotype with a unique expression pattern.
- Understanding IgD's developmental trajectory in healthy children is essential for interpreting immunological assessments.
Purpose of the Study:
- To determine the normal levels and detectability of Immunoglobulin D (IgD) in healthy children across different age groups.
- To establish reference ranges for IgD in pediatric populations.
Main Methods:
- Quantitative analysis of serum Immunoglobulin D (IgD) levels.
- Study population included 139 healthy children aged 0 to 14 years.
- Age-stratified analysis of IgD concentrations and detection rates.
Main Results:
- Immunoglobulin D (IgD) was undetectable in umbilical cord blood and infant serum samples.
- Average serum IgD levels in children over 1 year of age were 35 IU/ml.
- No significant IgD level variations were observed in older age groups, but detectability increased with age.
Conclusions:
- Serum Immunoglobulin D (IgD) is typically absent in early life and emerges after the first year.
- Pediatric reference ranges for IgD should consider age-specific detectability and stable levels post-infancy.
Abstract:
IgD level examination was performed in 139 healthy children in various age groups (from birth till 14 years). There was no IgD in umbilical cord blood neither in infant serum. In children over 1 year of age, average IgD level was 35 IU/m1 and no significant differences were found in higher age groups. Nevertheless the percentage of detectability was growing with age of children.