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Intensive plasma exchange--effects on haemostasis
Our results show that 4L. plasma exchange with coagulation factor free fluids even when carried out on a daily basis for 7 or more days is a relatively safe procedure. Despite gross abnormalities of coagulation screening tests, and coagulation factor levels, spontaneous haemorrhagic incidents occur very rarely (5/815; 0.61%) and no thrombotic episodes were observed. Routine replacement with fresh frozen plasma is therefore not required to maintain normal haemostasis although prophylactic platelet concentrates would be advisable if the platelet count falls below 30 x 10(9)/1.
Our results show that 4L. plasma exchange with coagulation factor free fluids even when carried out on a daily basis for 7 or more days is a relatively safe procedure. Despite gross abnormalities of coagulation screening tests, and coagulation factor levels, spontaneous haemorrhagic incidents occur very rarely (5/815; 0.61%) and no thrombotic episodes were observed. Routine replacement with fresh frozen plasma is therefore not required to maintain normal haemostasis although prophylactic platelet concentrates would be advisable if the platelet count falls below 30 x 10(9)/1.