Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A sensitive and selective monkey conflict test

J B Patel, B Migler

    Pharmacology, Biochemistry, and Behavior
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence of Association of CYP1A1 Expression in Blood Lymphocytes and Clinicopathological Variables in Oral Cancer.

    Indian journal of clinical biochemistry : IJCB·2022
    Same author

    Structural and Volumetric Brain MRI Findings in Mild Traumatic Brain Injury.

    AJNR. American journal of neuroradiology·2020
    Same author

    Genetic analysis of first lactation production traits in Kankrej cattle.

    Veterinary world·2016
    Same author

    High potential source for biomass degradation enzyme discovery and environmental aspects revealed through metagenomics of Indian buffalo rumen.

    BioMed research international·2014
    Same author

    Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from Gujarat, West India.

    Oral diseases·2013
    Same author

    Leucas aspera: A review.

    Pharmacognosy reviews·2012
    Same journal

    Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2026
    See all related articles

    This study introduces a conflict model for testing antianxiety drugs. Effective anxiolytics, like benzodiazepines, significantly increased punished responses in squirrel monkeys, aiding in the identification of new anxiety treatments.

    Area of Science:

    • * Behavioral neuroscience
    • * Pharmacology
    • * Primate models

    Background:

    • * The need for reliable methods to identify effective antianxiety agents is critical.
    • * Existing models may not accurately predict clinical efficacy in humans.

    Purpose of the Study:

    • * To describe and validate a conflict model in squirrel monkeys for assessing potential antianxiety drugs.
    • * To determine if clinically effective anxiolytics show specific activity in this model.

    Main Methods:

    • * Squirrel monkeys were trained on a food-reinforced bar-pressing task.
    • * A 6-hour session included a 3-hour punished period followed by a 3-hour unpunished period.
    • * The effects of various psychoactive agents on punished responding were evaluated.

    Related Experiment Videos

    Main Results:

    • * Benzodiazepines (chlordiazepoxide, diazepam) and non-benzodiazepines (meprobamate, phenobarbital) significantly increased punished responding.
    • * Other tested agents (e.g., amphetamine, chlorpromazine, ethanol) did not increase punished responding.
    • * The model demonstrated sensitivity, selectivity, and stable baselines.

    Conclusions:

    • * The described conflict model effectively identifies compounds with antianxiety properties in primates.
    • * This primate model is a valuable tool for discovering novel anxiolytic agents.
    • * The model's characteristics support its utility in preclinical drug screening.