Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating immune complexes in healthy persons

H Jans, E Dybkjaer, P Halberg

    Scandinavian Journal of Rheumatology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sci-Fri PM: Planning-02: MRI-based radiation treatment planning for an MRI-linac system.

    Medical physics·2017
    Same author

    Medical care and organisation at the 2012 Roskilde Music Festival: a prospective observational study.

    Acta anaesthesiologica Scandinavica·2014
    Same author

    Circulating microparticles and plasma levels of soluble E- and P-selectins in patients with systemic sclerosis.

    Scandinavian journal of rheumatology·2013
    Same author

    Impact of a physician-staffed helicopter on a regional trauma system: a prospective, controlled, observational study.

    Acta anaesthesiologica Scandinavica·2013
    Same author

    Shape-controlled synthesis of NIR absorbing branched gold nanoparticles and morphology stabilization with alkanethiols.

    Nanotechnology·2010
    Same author

    Impact of pre-concentration to covalently biofunctionalize suspended nanoparticles.

    Nanotechnology·2010
    Same journal

    Sámi psoriatic arthritis patients in northern Norway receive less conventional synthetic disease-modifying anti-rheumatic drug treatment and have more arthritis, axial symptoms, and joint damage.

    Scandinavian journal of rheumatology·2026
    Same journal

    Distinct clinical outcomes of positron emission tomography/computed tomography-based subtypes in treatment-naïve Takayasu arteritis.

    Scandinavian journal of rheumatology·2026
    Same journal

    Elevated serum immunoglobulin A predicts extra-articular manifestations in axial spondyloarthritis.

    Scandinavian journal of rheumatology·2026
    Same journal

    Multimodal imaging in the diagnosis of iliopsoas bursitis complicating biological therapy in rheumatoid arthritis: a case report with therapeutic implications.

    Scandinavian journal of rheumatology·2026
    Same journal

    Real-world clinical outcomes of patients with disproportionate articular pain in rheumatoid arthritis: ANSWER cohort study.

    Scandinavian journal of rheumatology·2026
    Same journal

    Cervical spine instability in axial spondyloarthritis: prevalence, patterns, and predictive factors in a high-risk cohort.

    Scandinavian journal of rheumatology·2026
    See all related articles

    Circulating immune complexes (CIC) are common in rheumatoid arthritis patients. Detecting CIC with complement activation products (C4 and C3 A.P.) and considering seasonal variations may improve diagnostic significance.

    Area of Science:

    • Immunology
    • Clinical Chemistry

    Background:

    • Circulating immune complexes (CIC) are implicated in various autoimmune diseases.
    • Assessing CIC and complement activation products (C4 and C3 A.P.) can offer insights into immune system activity.

    Purpose of the Study:

    • To investigate the prevalence of CIC and C4/C3 A.P. in different populations.
    • To explore the relationship between CIC, C4/C3 A.P., rheumatoid arthritis, and seasonal factors.

    Main Methods:

    • Sera from blood donors, hospital staff, and rheumatoid arthritis patients were analyzed.
    • Circulating immune complexes (CIC) were detected using complement consumption and PEG precipitation tests.
    • C4 and C3 activation products (C4 and C3 A.P.) were measured via crossed immunoelectrophoresis.

    Related Experiment Videos

    Main Results:

    • No significant difference in CIC prevalence was observed between healthy controls (blood donors and staff).
    • A higher incidence of CIC was noted in hospital staff during winter months.
    • CIC were detected in 86% of rheumatoid arthritis patients, with significantly more C4/C3 A.P. present in CIC-positive sera.

    Conclusions:

    • Simultaneous detection of CIC and C4/C3 A.P. may enhance diagnostic utility.
    • Seasonal variations and complement activation products are important considerations when interpreting CIC test results.