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Renal function after nephrectomy in renal donors

M Hida, T Iida, T Shimbo

    The Tokai Journal of Experimental and Clinical Medicine
    |July 1, 1982
    PubMed
    Summary
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    Renal donors show good kidney function recovery six months to five years post-nephrectomy, with some blood chemistry changes and compensatory kidney growth. Early complications occurred in 32% of donors.

    Area of Science:

    • Nephrology
    • Transplant Surgery
    • Urology

    Background:

    • Living kidney donation involves nephrectomy, necessitating evaluation of long-term renal function and donor safety.
    • Understanding the functional and structural adaptations of the remaining kidney is crucial for donor well-being.

    Purpose of the Study:

    • To assess the long-term renal function and compensatory changes in living kidney donors after nephrectomy.
    • To document the incidence and types of early and late complications in renal donors.

    Main Methods:

    • Longitudinal study of 34 renal donors.
    • Assessment of creatinine clearance and PSP tests at 6 months to 5 years post-nephrectomy.
    • Monitoring of blood urea nitrogen, creatinine, and uric acid levels.
    • Evaluation of remaining kidney size via imaging for compensatory hypertrophy.

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    Main Results:

    • Creatinine clearance and PSP test performance recovered to 81.8% and 68.2% of pre-nephrectomy levels, respectively.
    • Blood urea nitrogen, creatinine, and uric acid levels increased by 24.9%, 36.7%, and 24.3%, respectively.
    • Compensatory hypertrophy of the remaining kidney was observed, with a mean size increase of 12.0% x 17.8%.
    • Early complications (pneumothorax, wound infection, hepatitis, UTI) occurred in 32% of donors.
    • One case of late neuralgic pain in the scar region was reported.

    Conclusions:

    • Living kidney donors exhibit significant renal function recovery and compensatory hypertrophy of the remaining kidney.
    • While generally safe, potential early and late complications should be monitored in renal donors post-nephrectomy.