[Interaction of spherical bilayer lipid membrane with liposomes]

This paper is concerned with the interaction of spherical bilayer lipid membranes with liposomes containing amphotericin B as an ionophore marker. Lecithin or lecithincholesterol liposomes did not change conduction of the spherical membrane irrespective of the presence of amphotericin in them. Administration of phosphatide acid and dicetyl phosphate to liposomes and a spherical membrane promoted the fusion of the membrane bilayers which was recorded from an increase in the membrane conduction and 86Rb+ efflux from its inter space. The use of spherical bilayer membranes having a large surface is shown possible in principle for studying fusion with liposomes as well as incorporation of different macromolecules into lipid bilayers.