[Rate of maturation of osteons]

This paper examines the dynamics of Havers'ian remodelling and the concept of maturation rate of poly-chrome fluorescence-labeling osteons by means measurements of bone formation. It was used cortical bone of rabbit and merino sheep on various experimental conditions (Normal bone growth in the diaphysis of large bone and cortical bone of iliac crest, secondary fracture healing in tibia osteosyntheses with external fixation and oligotrophic pseudoarthrosis in rabbit. Gap healing of fractures in tibia osteosyntheses with external fixation and compression in the sheep). The diameters of labels were measured and the mathematical function of maturation rate of osteons was made out. The results were compared on the different experiment conditions. Statistical analyses have shown that the results of mathematical function and the values of their constants are not significantly different. These results seem to suggest that the rate of formation of the osteon is optimal on the various conditions and it is not use stimulating the osteoblastic activity with stimulation-therapy. The described model shows important informations of bone remodeling and adds new facts to the understanding of formal genesis of bone growth and fracture healing.