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[Toxigenicity of NAG-vibrio isolated from patients and disease carriers]
Abstract:
The article deals with the in vitro determination of toxigenicity in 311 NAG vibrio strains isolated from patients with acute intestinal diseases and from healthy persons. Enterotoxin-synthesizing strains have been found to occur among NAG vibrios isolated from patients as frequently as among strains from healthy persons. The latter ones have also proved to be weaker as toxin producers. Comparative determination of virulence and toxigenicity in 54 NAG vibrio strains has demonstrated a significant prevalence of cultures with weak virulence over those with weak toxigenicity.
Insights
Toxigenicity testing in 311 NAG vibrio strains revealed similar enterotoxin-producing capabilities in strains from patients and healthy individuals. However, healthy individuals harbored weaker toxin-producing NAG vibrio strains.
Area of Science:
- Microbiology
- Bacteriology
- Infectious Diseases
Background:
- NAG vibrio (non-O1/O139 Vibrio cholerae) infections can cause acute intestinal diseases.
- Understanding the toxigenicity and virulence of NAG vibrio strains is crucial for disease management.
- Previous studies have explored the pathogenicity of various Vibrio species.
Purpose of the Study:
- To determine the in vitro toxigenicity of NAG vibrio strains.
- To compare toxigenicity and virulence between strains isolated from patients and healthy individuals.
- To investigate the relationship between virulence and toxigenicity in NAG vibrio.
Main Methods:
- Isolation of 311 NAG vibrio strains from patients with acute intestinal diseases and healthy persons.
- In vitro determination of enterotoxin synthesis in isolated strains.
- Comparative assessment of virulence and toxigenicity in a subset of 54 NAG vibrio strains.
Main Results:
- Enterotoxin-synthesizing NAG vibrio strains were found with similar frequency in both patient and healthy populations.
- NAG vibrio strains from healthy persons exhibited weaker toxin production compared to those from patients.
- Comparative analysis showed a significant prevalence of cultures with weak virulence over those with weak toxigenicity.
Conclusions:
- NAG vibrio strains capable of enterotoxin synthesis are present in both diseased and healthy individuals.
- Strains from healthy individuals may represent a reservoir but are generally less potent toxin producers.
- Weak virulence in NAG vibrio strains is more common than weak toxigenicity, suggesting complex pathogenicity factors.