Reserpine effect on gastric secretion during exercise and restitution in healthy subjects

The purpose of the work was determination of reserpine effect on basal gastric secretion and on electrolytes in the gastric juice during exercise and restitution in 10 healthy men aged 20-24 years. Gastric secretion was determined during three successive hours: at rest, during exercise, and during restitution. The investigation was performed twice at an interval of 3-5 days. Before the second investigation all subjects received intramuscularly reserpine 2.5 mg. The exercise performed by each subject included work on a Monark cycle ergometer at a mean workload of 29280 +/- 5904 kpm/hour. Reserpine administration caused that during the exercise the value of BAO (basal acid output) was highly significantly increased (p less than 0.001) due to increased gastric juice volume (p less than 0.005) and hydrochloric acid concentration (p less than 0.001). Moreover, the total secretion of sodium and potassium with gastric juice was increased (p less than 0.005). These changes persisted also during restitution.