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Provocation with cow's milk and cereals in atopic dermatitis
Acta Dermato-Venereologica
|January 1, 1977
Summary
Food sensitivity exacerbates atopic dermatitis in young children. While some children outgrow allergies, initial allergy tests like radioallergosorbent test (RAST) have limited value for screening in these cases.
Area of Science:
- Pediatrics
- Allergology
- Immunology
Background:
- Atopic dermatitis is common in children under 5.
- Food sensitivity can trigger or worsen atopic dermatitis.
- Accurate diagnostic tools for food sensitivity in atopic dermatitis are needed.
Purpose of the Study:
- To investigate the role of oral food provocation in identifying food sensitivities in children with atopic dermatitis.
- To assess changes in food sensitivity over time.
- To evaluate the utility of serological markers and radioallergosorbent testing (RAST) in diagnosing food sensitivity.
Main Methods:
- Oral provocation tests with cow's milk and cereals were conducted in 81 children under 5 with atopic dermatitis.
- Positive reactors underwent repeated provocation over 18 months.
- Serum IgE, specific reagins, and RAST were analyzed.
Main Results:
- 15 out of 81 children showed dermatitis exacerbation after food provocation.
- Eleven children lost sensitivity, and 2 became more tolerant over 18 months.
- Initial IgE and specific reagins did not predict positive provocation; however, reagins to egg white increased in positive reactors. RAST showed limited screening value.
Conclusions:
- Oral food provocation is effective in identifying food triggers for atopic dermatitis in young children.
- Food sensitivity in atopic dermatitis can change over time, with some children outgrowing it.
- Standard allergy tests like RAST have limited utility for screening food sensitivity in atopic dermatitis.