Related Experiment Video
Updated: Aug 19, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
Published on: April 19, 2017
Abstract:
We report a case of rhinocerebral mucormycosis associated with diabetic ketoacidosis. The features of this rare, fulminating, fungal infection were not appreciated because of ignorance about the condition. The typical features include continued drowsiness in spite of correction of the diabetic ketoacidosis, black ulcer of the palate, septum or turbinate, facial pain, and cellulitis with varying eye and neurological signs. The general aspects of the infection are discussed, emphasizing that the mainstay of treatment is correction of the underlying condition, surgical debridement, and intravenous amphotericin B. Awareness of the condition will enable early diagnosis and adequate treatment to ensure the best chance of survival.
Insights
Rhinocerebral mucormycosis, a rare fungal infection, can be fatal if not diagnosed early. Prompt treatment, including managing diabetic ketoacidosis and antifungal therapy, is crucial for survival.
Area of Science:
- Mycology
- Infectious Diseases
- Endocrinology
Background:
- Diabetic ketoacidosis (DKA) is a serious complication of diabetes.
- Mucormycosis is a rare but aggressive fungal infection.
Observation:
- A case of rhinocerebral mucormycosis occurred in a patient with DKA.
- Symptoms included persistent drowsiness despite DKA treatment, facial pain, and black necrotic lesions in the palate or nasal structures.
Findings:
- The infection's severity was initially underestimated due to lack of awareness.
- Early recognition of specific clinical signs is vital for timely intervention.
Implications:
- Increased awareness of rhinocerebral mucormycosis in DKA patients is essential for early diagnosis.
- Multifaceted treatment, including DKA management, surgical debridement, and amphotericin B, improves patient outcomes.
- Prompt diagnosis and treatment significantly enhance survival chances.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
Fungal Group Zygomycota
Cryptococcal Meningitis
Candidiasis
Bacterial Meningitis I: Introduction

