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Related Experiment Videos

Improved phosphate clearances with polycarbonate membranes

L W Fleming, S W Hudson, W K Stewart

    Clinical and Experimental Dialysis and Apheresis
    |January 1, 1982
    PubMed
    Summary
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    Polycarbonate dialysers show comparable urea and creatinine clearance to cellulose dialysers but offer significantly higher phosphate clearance. Their performance is affected by transmembrane pressure (TMP), with clearances decreasing as TMP increases.

    Area of Science:

    • Nephrology
    • Biomaterials Science
    • Renal Replacement Therapy

    Background:

    • Haemodialysis is a critical treatment for end-stage renal disease, relying on dialysers to remove waste products.
    • Cellulose-based dialysers are commonly used, but advancements seek improved solute clearance and biocompatibility.
    • Polycarbonate dialysers represent a newer material with potential benefits for haemodialysis efficacy.

    Purpose of the Study:

    • To evaluate the clearance performance of polycarbonate dialysers for urea, creatinine, and inorganic phosphate.
    • To compare polycarbonate dialyser performance against traditional cellulose-based dialysers.
    • To investigate the effect of transmembrane pressure (TMP) on polycarbonate dialyser solute clearance.

    Main Methods:

    • Conducted clearance studies using polycarbonate dialysers in two patients undergoing maintenance haemodialysis.

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  • Performed 20 study sessions, measuring plasma concentrations of urea, creatinine, and inorganic phosphate.
  • Calculated solute clearances using measured blood flow and plasma flow, analyzing the impact of varying TMP.

    • Main Results:

    • Urea and creatinine clearances with polycarbonate dialysers were comparable to those achieved with cellulose dialysers.
    • Phosphate clearances were significantly higher, averaging over 70% of urea clearances.
    • All solute clearances decreased as TMP increased, differing from cellulose membrane behavior.

    Conclusions:

    • Polycarbonate dialysers offer enhanced relative phosphate clearance compared to cellulose dialysers.
    • The inverse relationship between TMP and clearance for polycarbonate dialysers warrants further investigation.
    • Polycarbonate dialysers present a promising alternative with potential advantages in phosphate removal during haemodialysis.