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Related Experiment Videos

Hydrogel implants for the correction of myopia

P S Binder

    Current Eye Research
    |January 1, 1982
    PubMed
    Summary

    Donut-shaped hydrogel lenses implanted in baboon corneas unexpectedly caused steepening, not flattening. Post-operative analysis revealed no inflammation but showed keratocyte lining and epithelial implantation within the pocket.

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    Cornea·1999

    Area of Science:

    • Ophthalmology
    • Biomaterials Science
    • Corneal Surgery

    Background:

    • Corneal flattening is a desired outcome for refractive correction.
    • Intralamellar corneal implants offer a potential method for refractive modification.
    • Hydrogel lenses are biocompatible materials investigated for ocular applications.

    Purpose of the Study:

    • To investigate the potential of intralamellar hydrogel lenses for inducing corneal flattening.
    • To evaluate the biocompatibility and tissue response to implanted hydrogel lenses in a baboon model.

    Main Methods:

    • Donut-shaped hydrogel lenses (7mm diameter) were implanted into intralamellar pockets created by a microkeratome in five baboon eyes.
    • Corneal topography was measured pre- and post-operatively.
    • Corneas were analyzed using correlative microscopy three to five months post-implantation.

    Main Results:

    • Implantation of 7mm hydrogel lenses resulted in significant corneal steepening, increasing diopters from 3.4 to 22.5.
    • Microscopic examination showed an absence of inflammation.
    • The intralamellar pocket was lined with keratocytes, and focal epithelial implantation was observed, while the corneal cap remained normal.

    Conclusions:

    • Intralamellar hydrogel lens implantation in baboons did not achieve corneal flattening but induced significant steepening.
    • The implanted hydrogel lenses demonstrated good biocompatibility with minimal adverse tissue reactions.
    • Further research is needed to understand the mechanism of steepening and optimize implant design for refractive correction.

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