[Treatment of mania by a calcium inhibitor. Preliminary study]

The authors are studying the effects on pure manic syndromes of reduction of intracytoplasmic ionised calcium through administration of a calcic inhibitor. Three wellknown bipolar patients (manic type) were significantly improved. One patient was quickly cured, but in this case (first access in a young man) spontaneous remission cannot be excluded. One patient was not improved, and presented a secondary manic state, related to a beginning cerebrary involution. These results, if confirmed, would orient future research in primary manic syndromes and in mode of action of lithium on calcic metabolism.