Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Case of tumour rickets

M W Moncrieff, D P Brenton, L J Arthur

    Archives of Disease in Childhood
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    A boy with bone tumors developed hypophosphataemic rickets, a condition linked to impaired phosphate reabsorption. This case highlights

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cushing's Syndrome with Non-endocrine Carcinoma.

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study.

    Arteriosclerosis, thrombosis, and vascular biology·2001
    Same author

    Adult care in phenylketonuria and hyperphenylalaninaemia: the relevance of neurological abnormalities.

    European journal of pediatrics·2000
    Same author

    The adult and adolescent clinic for inborn errors of metabolism.

    Journal of inherited metabolic disease·2000
    Same author

    Cutis verticis gyrata of the scalp in a patient with autosomal dominant insulin resistance syndrome.

    Clinical and experimental dermatology·2000
    Same author

    Phenylketonuria: treatment in adolescence and adult life.

    European journal of pediatrics·1996

    Area of Science:

    • Pediatric Endocrinology
    • Oncology
    • Nephrology

    Background:

    • Hypophosphataemic rickets is a disorder characterized by impaired renal tubular reabsorption of phosphate, leading to bone abnormalities.
    • Tumor-induced osteomalacia (TIO) or rickets is a rare condition where neoplasms cause phosphate wasting.
    • This case involves a pediatric patient with extensive bone tumors.

    Observation:

    • A 10-year-old boy presented with widespread soft tissue tumors of bone.
    • He developed hypophosphataemic rickets, confirmed by biochemical tests excluding other causes.
    • Biopsy of the largest tumor revealed a non-ossifying fibroma.

    Findings:

    • The patient's condition is consistent with 'tumor rickets', a form of rickets caused by a tumor.
    • Unlike typical TIO cases, surgical tumor removal was not feasible due to the widespread nature of the tumors.

    Related Experiment Videos

  • Treatment required high doses of vitamin D and oral phosphate for rickets healing.

    • Implications:

    • This case supports the hypothesis that tumors can produce a phosphaturic hormone, leading to rickets.
    • The management of tumor rickets may require medical therapy when surgical intervention is not possible.
    • Further research into the mechanisms of phosphaturic hormone production by tumors is warranted.