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[Shock liver]

K Lenz, G Kleinberger, W Druml

    Leber, Magen, Darm
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Severe shock can cause liver damage, specifically central lobular necrosis, often undiagnosed due to subtle symptoms and late enzyme elevation. This liver injury in shock patients has a high mortality rate.

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    Area of Science:

    • Hepatology
    • Critical Care Medicine
    • Pathology

    Context:

    • Severe shock, regardless of origin, can lead to hepatic complications.
    • Liver damage in shock is often overlooked due to non-specific clinical signs and delayed biochemical markers.
    • A 10-year study at Vienna Medical School's ICU identified 32 cases of shock-induced liver damage.

    Purpose:

    • To investigate the incidence and characteristics of hypoxic, central lobular necrosis of the liver in patients experiencing severe shock.
    • To highlight the diagnostic challenges and clinical outcomes associated with shock-related liver injury.

    Summary:

    • Hypoxic, central lobular necrosis of the liver was identified in 32 out of 3,788 intensive care unit patients over 10 years.
    • Diagnosis was primarily based on elevated SGPT (serum glutamic-pyruvic transaminase) levels, confirmed by biopsy in some cases.

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  • Common causes of shock included myocardial infarction, pulmonary infarction, and cardiac/pulmonary events, with a high lethality rate of 78.1%.

    • Impact:

    • This study underscores the significance of recognizing liver damage as a critical complication of severe shock.
    • Findings emphasize the need for heightened clinical suspicion and timely diagnostic evaluation in shock patients presenting with potential hepatic involvement.
    • The high mortality associated with this condition highlights the urgency for improved management strategies in critical care settings.