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Familial systemic lupus erythematosus

K J Buckman, S K Moore, A J Ebbin

    Archives of Internal Medicine
    |November 1, 1978
    PubMed
    Summary
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    Systemic lupus erythematosus (SLE) shows familial aggregation, with 12% of patients having affected relatives. Analysis of pedigrees suggests multifactorial inheritance patterns for SLE, rather than simple Mendelian inheritance.

    Area of Science:

    • Rheumatology
    • Genetics
    • Immunology

    Background:

    • Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
    • Understanding the genetic basis of SLE is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the familial aggregation and inheritance patterns of SLE.
    • To determine if SLE follows simple Mendelian inheritance or suggests a more complex genetic model.

    Main Methods:

    • Collected pedigrees from 340 SLE patients.
    • Analyzed family histories for affected relatives.
    • Examined individual pedigrees for patterns of autosomal dominant, autosomal recessive, and sex-linked inheritance.

    Main Results:

    • 12% of SLE patients (41 out of 340) had at least one affected relative.

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  • Male patients (30%) had a higher rate of familial SLE compared to female patients (10%).
  • Individual pedigrees showed possible Mendelian inheritance, but the overall group suggested multifactorial inheritance.

    • Conclusions:

    • SLE exhibits familial aggregation, indicating a genetic component.
    • Simple Mendelian inheritance models do not fully explain SLE patterns.
    • Multifactorial inheritance is the most likely genetic model for systemic lupus erythematosus.