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[Application of nude mouse-human cancer xenograft system for sensitivity test of anticancer drugs]
Abstract:
The usefulness of the nude mouse-human cancer xenograft system for a sensitivity test of chemotherapeutic drugs is evaluated. In our present study, the response of 9 experimental chemotherapies on 7 lines of cancer xenografts in nude mice was directly compared with clinical response in each donor patient, to the same chemotherapy and good correlation was found between these respective results. Experimental studies on chemotherapeutic effects on 14 lines of cancer xenografts (7 gastric, 3 colorectal, 3 breast and 1 pancreatic cancer) using 5 clinically active and 5 new drugs, were also conducted Although every line of xenograft retained different patterns of sensitivity to the various agents, drugs which were clinically effective to a type of tumor were found to be also sensitive against the same type of xenografts in nude mice. Thus the nude-mice human cancer system were is thought to be useful as a predictive secondary screening for new drugs. However, further improvement is necessary to establish this system as a more accurate selection method for anti-cancer drugs.
Insights
The nude mouse-human cancer xenograft model effectively predicts chemotherapy response, showing good correlation with patient outcomes. This system aids in evaluating new anti-cancer drugs and improving treatment selection.
Area of Science:
- Oncology
- Pharmacology
- Translational Medicine
Context:
- The development of novel anti-cancer drugs requires accurate preclinical sensitivity testing.
- Nude mouse-human cancer xenografts are utilized to model human tumors for drug evaluation.
- Direct comparison of xenograft and patient responses is crucial for validating preclinical models.
Purpose:
- To evaluate the utility of the nude mouse-human cancer xenograft system as a predictive tool for chemotherapeutic drug sensitivity.
- To compare the efficacy of experimental chemotherapies in xenografts with clinical responses in patients.
- To assess the potential of this model for secondary screening of new anti-cancer agents.
Summary:
- A study compared the response of 9 experimental chemotherapies in 7 human cancer xenografts grown in nude mice against clinical patient responses to the same drugs, finding a good correlation.
- Further experiments tested 14 cancer xenograft lines (gastric, colorectal, breast, pancreatic) against 10 drugs, confirming that clinically effective drugs showed sensitivity in corresponding xenografts.
- The nude mouse-human cancer xenograft system demonstrates promise as a predictive secondary screening tool for new anti-cancer drugs.
Impact:
- This research supports the use of nude mouse-human cancer xenografts as a valuable preclinical model for predicting drug efficacy in oncology.
- The findings suggest that this system can aid in the selection and development of more effective anti-cancer therapies.
- Further refinement of the xenograft model is recommended to enhance its accuracy as a drug selection method.