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Pineal tumors. A 53-year experience
Archives of Neurology
|November 1, 1978
Summary
This study reviewed 34 primary pineal tumors in adolescent boys, primarily germ cell or pineal cell types. Surgical intervention for these pineal tumors showed high early mortality but improved outcomes over time.
Area of Science:
- Neurology
- Neurosurgery
- Pediatric Oncology
Background:
- Pineal tumors are rare neoplasms affecting the pineal gland.
- Germ cell and pineal cell tumors represent the most common types.
- Clinical presentation often includes increased intracranial pressure and Parinaud's syndrome.
Purpose of the Study:
- To review the clinical characteristics and outcomes of primary pineal tumors.
- To evaluate the efficacy and safety of surgical interventions over time.
Main Methods:
- Retrospective analysis of 34 patients with pathologically confirmed primary pineal tumors.
- Data collected from 1923 to 1976 at the Mayo Clinic.
- Tumor classification based on cell of origin (germ cell or pineal cell).
Main Results:
- Most patients were adolescent males presenting with subacute increased intracranial pressure and Parinaud's syndrome.
- Hypothalamic symptoms were infrequently observed.
- Direct surgical intervention had a high initial mortality rate, with improvements noted in later years.
Conclusions:
- Primary pineal tumors, predominantly in adolescent boys, present with specific neurological syndromes.
- Surgical management of pineal tumors has evolved, showing reduced mortality with advancements.
- Further research into optimal treatment strategies for pineal neoplasms is warranted.