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[Clinical study of phase analysis by RI multigated method]

T Mitani, M Ueda, N Yamada

    Journal of Cardiography
    |September 1, 1982
    PubMed
    Summary
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    Phase analysis effectively quantifies ventricular asynchrony, showing a strong correlation between reduced left ventricular ejection fraction and increased phase standard deviation. This method aids in understanding cardiac timing abnormalities.

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Physiology

    Background:

    • Ventricular asynchrony is a significant factor in various cardiac conditions.
    • Accurate quantification of asynchrony is crucial for patient management and treatment strategies.

    Purpose of the Study:

    • To evaluate the utility of phase analysis using the RI multigated method for quantifying ventricular asynchrony.
    • To explore the correlation between phase analysis parameters and left ventricular ejection fraction (LVEF).

    Main Methods:

    • Phase analysis was conducted on 32 patients with diverse cardiac conditions using the RI multigated method.
    • Ventricular asynchrony was quantified by calculating the standard deviation (S.D.) of phase from a histogram representing one cardiac cycle.
    • Pixel data was plotted into a histogram over 360 degrees of the cardiac cycle.

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    Main Results:

    • Phase analysis proved to be a valuable parameter for assessing cardiac asynchrony.
    • A significant negative correlation (r = -0.86) was found between LVEF and phase S.D.
    • Marked time lags were observed in infarcted areas, with milder lags in right and left bundle branch blocks (RBBB and LBBB).
    • Time lag between ventricles was reduced or reversed in RBBB with left anterior hemiblock compared to isolated RBBB.

    Conclusions:

    • Phase analysis is a reliable method for quantifying ventricular asynchrony.
    • Reduced LVEF is associated with increased ventricular asynchrony.
    • Phase analysis can help differentiate the degree of asynchrony in various heart conditions like myocardial infarction and bundle branch blocks.