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Urinary phencyclidine excretion in chronic abusers

G M Simpson, A M Khajawall, E Alatorre

    Journal of Toxicology. Clinical Toxicology
    |December 1, 1982
    PubMed
    Summary
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    Chronic phencyclidine (PCP) abusers are typically young males with long-term, frequent use. Urine samples show rapid PCP excretion within 14 days after cessation of use.

    Area of Science:

    • Forensic Toxicology
    • Addiction Medicine
    • Pharmacokinetics

    Background:

    • Phencyclidine (PCP) abuse is a significant public health concern.
    • Understanding PCP usage patterns and excretion is crucial for clinical and forensic settings.

    Purpose of the Study:

    • To investigate the usage patterns of chronic phencyclidine abusers.
    • To determine the urinary excretion profile of PCP in this population.

    Main Methods:

    • Collected usage data from 100 hospitalized chronic PCP abusers.
    • Monitored weekly urine samples using gas chromatographic nitrogen detector analysis for PCP.

    Main Results:

    • Abusers were predominantly young males with an average of 40 months of PCP use (3-4 days/week).

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  • Urine samples became PCP-negative within a mean of 14 days (range: <30 days) after last use.
  • Rapid PCP excretion observed in the first 9 days, followed by a slower decline.

    • Conclusions:

    • Chronic PCP abuse is characterized by long-term, frequent use in young males.
    • Urinary PCP levels decline rapidly after cessation, with most individuals clearing the drug within 30 days.