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Corneal histology after epidemic keratoconjunctivitis
Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1978
Summary
Epidemic keratoconjunctivitis can cause lasting corneal opacities and visual disturbances, even without steroid treatment. Histopathology revealed stromal changes but no viral particles, suggesting non-viral causes for late complications.
Area of Science:
- Ophthalmology
- Virology
- Histopathology
Background:
- Epidemic keratoconjunctivitis (EKC) is a viral eye infection.
- Corneal opacities can lead to significant visual impairment.
- Steroid treatment is often used to manage inflammation in EKC.
Observation:
- A 67-year-old woman developed corneal opacities and visual disturbances two years after EKC symptoms.
- She did not receive locally effective steroid treatment for her initial EKC.
- A lamellar graft was performed due to severe visual disturbances.
Findings:
- Corneal histopathology showed changes in the superficial stroma and Bowman's membrane.
- Lymphocytic infiltration was observed in the stroma and epithelium.
- Electron microscopy did not detect any virus-like particles.
Implications:
- This case suggests that non-viral factors may contribute to late corneal complications after EKC.
- Understanding the pathogenesis of post-EKC corneal changes is crucial for effective management.
- Further research is needed to elucidate the mechanisms behind these persistent visual disturbances.