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The pseudoexfoliation syndrome
Metabolic, Pediatric, and Systemic Ophthalmology
|January 1, 1982
Summary
The term pseudoexfoliation syndrome is supported, with fibrils originating from the iris and ciliary body epithelium. Granular deposits on the lens capsule stem from iris contact, not lens epithelium.
Area of Science:
- Ophthalmology
- Cell Biology
- Pathology
Background:
- Pseudoexfoliation syndrome is characterized by fibrillar deposits.
- The origin of these exfoliative fibrils remains a subject of investigation.
Purpose of the Study:
- To review the clinical and ultramicroscopic findings in pseudoexfoliation syndrome.
- To clarify the cellular sources of exfoliative fibrils and their deposition patterns.
Main Methods:
- Clinical examination of the eye.
- Scanning and transmission electron microscopy of the lens.
- Microscopic analysis of ocular tissues in pseudoexfoliation syndrome.
Main Results:
- The lens epithelium, iris pigment epithelium, and ciliary body epithelium are identified as likely sources of exfoliative fibrils.
- Granular material on the lens capsule is localized to areas of iris contact.
- Continuing deposits after cataract extraction suggest an external source, likely the iris.
Conclusions:
- The term pseudoexfoliation should be retained for this condition.
- Exfoliative fibrils originate from ocular epithelia, with the iris playing a key role in depositing material onto the lens capsule.