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The pseudoexfoliation syndrome

H S Sugar

    Metabolic, Pediatric, and Systemic Ophthalmology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The term pseudoexfoliation syndrome is supported, with fibrils originating from the iris and ciliary body epithelium. Granular deposits on the lens capsule stem from iris contact, not lens epithelium.

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    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Pathology

    Background:

    • Pseudoexfoliation syndrome is characterized by fibrillar deposits.
    • The origin of these exfoliative fibrils remains a subject of investigation.

    Purpose of the Study:

    • To review the clinical and ultramicroscopic findings in pseudoexfoliation syndrome.
    • To clarify the cellular sources of exfoliative fibrils and their deposition patterns.

    Main Methods:

    • Clinical examination of the eye.
    • Scanning and transmission electron microscopy of the lens.
    • Microscopic analysis of ocular tissues in pseudoexfoliation syndrome.

    Main Results:

    • The lens epithelium, iris pigment epithelium, and ciliary body epithelium are identified as likely sources of exfoliative fibrils.

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  • Granular material on the lens capsule is localized to areas of iris contact.
  • Continuing deposits after cataract extraction suggest an external source, likely the iris.

    • Conclusions:

    • The term pseudoexfoliation should be retained for this condition.
    • Exfoliative fibrils originate from ocular epithelia, with the iris playing a key role in depositing material onto the lens capsule.