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Clonidine

F J Macri, S J Cevario

Archives of Ophthalmology (Chicago, Ill. : 1960)

|November 1, 1978

Summary

This summary is machine-generated.

Clonidine hydrochloride causes vasoconstriction in the cat eye by stimulating alpha-adrenergic receptors. This drug reduces aqueous humor production by constricting blood vessels in the ciliary processes.

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Area of Science:

Ophthalmology
Pharmacology
Neuroscience

Background:

Clonidine hydrochloride is known to affect the autonomic nervous system.
Alpha-adrenergic receptors play a role in ocular hemodynamics.

Purpose of the Study:

To investigate the mechanism of clonidine hydrochloride-induced vasoconstriction in the anterior segment of the cat eye.
To determine the effect of clonidine on aqueous humor production.

Main Methods:

Utilized an intact, enucleated, arterially perfused cat eye model.
Administered clonidine hydrochloride to assess its effects on ocular vasculature and fluid dynamics.

Main Results:

Clonidine hydrochloride induced vasoconstriction in the anterior segment of the cat eye.

The vasoconstrictive effect is mediated by direct stimulation of alpha-adrenergic receptors.

Clonidine hydrochloride decreased the rate of aqueous humor production.

Conclusions:

Clonidine hydrochloride decreases aqueous humor formation.
The mechanism involves the constriction of afferent ciliary process blood vessels, similar to other adrenergic agents.