Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluoride absorption through the hamster cheek pouch: a pH-dependent event

G M Whitford, R S Callan, H S Wang

    Journal of Applied Toxicology : JAT
    |December 1, 1982
    PubMed
    Summary

    Fluoride absorption in hamster cheek pouches is pH-dependent, primarily occurring via non-ionic HF diffusion. Other tested substances showed no such pH influence, indicating a specific fluoride transport mechanism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [STING-associated vasculopathy with onset in infancy: a case report].

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026
    Same author

    [Clinicopathological characteristics and prognostic factors in 36 cases of early-stage gastric mixed adenoneuroendocrine carcinoma].

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
    Same author

    Extracellular Z-DNA Enhances Cariogenicity of Biofilm.

    Journal of dental research·2025
    Same author

    [Interim efficacy of a multicenter cohort study for China Net Childhood Lymphoma mature B-cell lymphoma 2017 regimen in the treatment of pediatric High-grade-B cell lymphoma].

    Zhonghua yi xue za zhi·2024
    Same author

    [Analysis of efficacy and prognosis of allogeneic hematopoietic stem cell transplantation for the treatment of combined immunodeficiency].

    Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
    Same author

    [A case of neonatal multi-system Langerhans cell histiocytosis treated by dabrafenib].

    Zhonghua er ke za zhi = Chinese journal of pediatrics·2023

    Area of Science:

    • Oral physiology
    • Epithelial transport
    • Fluoride biochemistry

    Background:

    • The hamster cheek pouch is a model for studying oral epithelial absorption.
    • Understanding fluoride absorption is crucial for dental health and toxicology.
    • Keratinized epithelia present unique challenges for solute transport.

    Purpose of the Study:

    • To investigate the influence of solution pH on the absorption of fluoride and other substances in the hamster cheek pouch.
    • To elucidate the mechanism of fluoride absorption across keratinized oral epithelium.
    • To determine the relationship between fluoride concentration and its absorption rate.

    Main Methods:

    • Fractional absorption of fluoride, 3H2O, 125I, and 14C-DMO were measured.
    • Experiments were conducted across a range of solution pH values.

    Related Experiment Videos

  • Absorption rates were assessed at varying fluoride concentrations (1-53 mM).

    • Main Results:

    • Fluoride absorption rate was inversely related to pH when the pH was below 5.
    • Absorption rates of 3H2O, 125I, and 14C-DMO were not significantly affected by solution pH.
    • Fractional absorption of fluoride and 3H2O remained constant across different fluoride concentrations.

    Conclusions:

    • Fluoride absorption in the hamster cheek pouch is pH-dependent, suggesting a specific transport mechanism.
    • The data strongly support the diffusion of non-ionic hydrogen fluoride (HF) as the primary route for fluoride absorption.
    • This mechanism highlights the importance of pH in modulating fluoride bioavailability in the oral cavity.