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Abstract:
The vaccine potential of different surface antigens of encapsulated bacteria is considered. It is concluded that only the capsular polysaccharides provide good protection. Polysaccharides are, however, thymus-independent antigens and the antibody response is strongly influenced by the age of the recipient and his naturally acquired immunity. For a long-lasting immunity the induction of mainly IgG antibodies is essential. Such a response can easily be induced by conjugates in which the polysaccharides have been attached to thymus-dependent carriers.