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Pathological changes in goats experimentally inoculated with Pseudomonas pseudomallei
National Institute of Animal Health Quarterly
|January 1, 1982
Summary
Pseudomonas pseudomallei infection in goats causes acute septicemic illness or chronic localized disease depending on inoculation route. Lesions and bacterial presence were confirmed in spleen and lungs, highlighting disease pathogenesis.
Area of Science:
- Veterinary Microbiology
- Pathology
- Infectious Diseases
Background:
- Pseudomonas pseudomallei is an emerging zoonotic pathogen.
- Melioidiosis, caused by P. pseudomallei, affects various animal species.
- Understanding goat melioidiosis is crucial for disease control and public health.
Purpose of the Study:
- To investigate the pathogenesis of Pseudomonas pseudomallei infection in goats.
- To compare disease manifestations following subcutaneous and intraperitoneal inoculation.
- To characterize the pathological and ultrastructural findings of goat melioidiosis.
Main Methods:
- Sixteen goats were inoculated with cultured Pseudomonas pseudomallei.
- Inoculation routes included subcutaneous and intraperitoneal.
- Clinical signs, gross lesions, bacterial isolation, and ultrastructural analysis were performed.
Main Results:
- Intraperitoneal inoculation led to acute septicemic illness with widespread micro-abscesses.
- Subcutaneous inoculation resulted in chronic, localized disease with large lesions in the spleen and lungs.
- Pseudomonas pseudomallei was isolated from abscesses, and bacilli were observed within macrophages ultrastructurally.
Conclusions:
- The route of inoculation significantly influences the clinical presentation and lesion distribution of Pseudomonas pseudomallei infection in goats.
- Spleen and lungs are key target organs for Pseudomonas pseudomallei in goats.
- Ultrastructural findings confirm intracellular bacterial presence within macrophages, suggesting a role in disease persistence.