[Treatment of tinea microsporum. Metabolic interference between phenobarbital and griseofulvin]

Two epileptic children treated with phenobarbital and suffering from tinea capitis, not responding to a long lasting treatment with Griseofulvin, healed only after phenobarbital has been discontinued. We ascribe our therapeutic problems to the metabolic interference of Griseofulvin with phenobarbital. We have measured the blood concentration of Griseofulvin several times in one of our 2 children and in a control of the same age living in the same dietary conditions and in the same conditions of Griseofulvin intake; these measurements confirm these data. The point of interest of this report is to draw attention on: -the pharmacologic hypotheses put forward to explain this drug interference, -the other factors of a bad therapeutic response to a treatment with Griseofulvin.