Ent-16 alpha-methylamino-3-methoxy-1,3,5(10)-estratrien-17 beta-ol hydrochloride, a selective anti-arrhytmic...

The title compound and its antipode with natural steroid configuration were synthesized and tested. Both compounds showed equal potency as anti-arrhythmic compounds. An additional effect found for the steroid with natural configuration was its plasma cholesterol lowering activity in the rat. This suggests that enantiosteroids may have a more selective action than the steroids with natural configuration.