Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Which are the leukaemic cells?

L G Lajtha

    Blood Cells
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Acute myeloid leukaemia (AML) development involves a long delay and successful remission. This suggests AML originates in pluripotent stem cells and the leukaemic stem line is a small, partially controlled cell population.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An inhibitory factor in pernicious anaemia serum.

    Clinical science·2014
    Same author

    Determination of the probability of self-renewal in haemopoietic stem cells: a puzzle.

    Blood cells·1983
    Same author

    Stem cells versus stem lines.

    Annals of the New York Academy of Sciences·1982
    Same author

    Tissues and stem cells.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·1982
    Same author

    Generation of osteoclasts in vitro.

    Journal of cell science·1981
    Same author

    The regulation of hemopoiesis in long-term bone marrow cultures. II. Stimulation and inhibition of stem cell proliferation.

    Blood·1980
    Same journal

    In vitro and in vivo studies of stromal niches.

    Blood cells·1994
    Same journal

    Differential manipulation of normal and chronic myeloid leukemia stem cell proliferation in vitro.

    Blood cells·1994
    Same journal

    Enrichment for primitive hemopoietic progenitors of marrow cells from 5-fluorouracil-treated mice and normal mice.

    Blood cells·1994
    Same journal

    Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily.

    Blood cells·1994
    Same journal

    Lysis of blood platelets by human osteosarcoma cells in vitro.

    Blood cells·1994
    Same journal

    Development of hemopoietic bone marrow within the ectopic bone induced by bone morphogenetic protein.

    Blood cells·1994
    See all related articles

    Area of Science:

    • Hematology
    • Oncology
    • Stem Cell Biology

    Background:

    • Acute myeloid leukaemia (AML) is characterized by a significant time lag between leukaemogenic stimulus and disease onset.
    • Long-term clinical remission is achievable in AML patients, indicating potential for disease control.

    Purpose of the Study:

    • To investigate the cellular origins and behavior of acute myeloid leukaemia.
    • To understand the implications of AML's long latency and remission potential on leukaemic cell dynamics.

    Main Methods:

    • Analysis of known clinical features of acute myeloid leukaemia in humans.
    • Inference of cellular mechanisms based on disease progression and remission data.

    Main Results:

    • The long latency suggests pluripotent stem cells are the primary targets for leukaemogenic insults in AML.

    Related Experiment Videos

  • Leukaemic stem cells likely represent a minor population within the total leukaemic cell mass.
  • The proliferation of leukaemic stem cells may remain partially regulated when their numbers are comparable to normal stem cells.

    • Conclusions:

    • Acute myeloid leukaemia pathogenesis involves the pluripotent stem cell.
    • The leukaemic stem cell population is small and potentially subject to residual regulatory control, explaining long remission durations.