Related Experiment Video

Updated: Aug 11, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Correlations of plasma high-density lipoprotein cholesterol levels with other plasma lipid and lipoprotein

C E Davis, D Gordon, J LaRosa

    Circulation
    |November 1, 1980
    PubMed

    Insights

    High-density lipoprotein (HDL) cholesterol associations with other lipids vary by age and sex, but not hormone use. This study analyzed lipid profiles in thousands of adults, finding HDL cholesterol negatively correlates with triglycerides and very low-density lipoprotein (VLDL) cholesterol.

    Area of Science:

    • Cardiovascular Research
    • Lipid Metabolism
    • Public Health

    Background:

    • Plasma lipoprotein levels are critical indicators of cardiovascular health.
    • Understanding the interrelationships between different lipoprotein fractions is essential for risk assessment.
    • Previous studies have suggested associations, but age and sex-specific variations require further investigation.

    Purpose of the Study:

    • To investigate the associations between high-density lipoprotein (HDL) cholesterol and other plasma lipid and lipoprotein fractions.
    • To examine how these associations vary by age, sex, and hormone use.
    • To compare findings with previous research on lipid profiles.

    Main Methods:

    • Analysis of plasma lipid and lipoprotein levels from the Lipid Research Clinics (LRC) Prevalence Study.
    • Inclusion of 3493 males and 3318 females across various age strata.
    • Calculation of correlation coefficients using logarithmic transformation, stratified by age, sex, and hormone use.

    Main Results:

    • Correlations of HDL cholesterol with other lipid fractions were strongly dependent on age and sex.
    • Age-dependent correlations within the 20-70 year range were accurately modeled by linear regression.
    • A weakly positive association was observed between HDL and total cholesterol, while a marked negative association existed between HDL cholesterol and triglyceride/VLDL cholesterol levels.

    Conclusions:

    • The relationship between HDL cholesterol and other lipoproteins is significantly influenced by age and sex.
    • Gonadal hormone use did not appear to affect these associations.
    • Findings align with existing literature, reinforcing the complex interplay of lipids in cardiovascular health.

    More Related Videos

    Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

    Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

    Published on: January 28, 2021

    High-Density Lipoprotein-Specific Phospholipid Efflux Assay07:08

    High-Density Lipoprotein-Specific Phospholipid Efflux Assay

    Published on: September 30, 2025

    Related Concept Videos

    Lipid-derived Compounds in the Human Body01:31

    Lipid-derived Compounds in the Human Body

    Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
    Fat-soluble Vitamins
    Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
    Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

    Lipid-Lowering Drugs: Statins and Miscellaneous Agents

    Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
    Lipids: Dietary Sources and Requirements01:18

    Lipids: Dietary Sources and Requirements

    Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
    Cholesterol: Significance and Regulation01:29

    Cholesterol: Significance and Regulation

    Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
    Considering cholesterol and...
    Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

    Blood Studies for Cardiovascular System III: Serum Lipid Profile

    Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
    Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
    Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
    Coronary Artery Disease IV: Preventive Measures01:26

    Coronary Artery Disease IV: Preventive Measures

    Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...