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Serum IgE levels in twins

P Sistonen, V Johnsson, M Koskenvuo

    Human Heredity
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Serum immunoglobulin E (IgE) levels showed frequent concordance in identical twins, but also notable discordance. This suggests a broad spectrum of how genetic factors influence IgE expression in adults.

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    Area of Science:

    • Immunology
    • Genetics
    • Twin studies

    Background:

    • Serum immunoglobulin E (IgE) is a key mediator in allergic responses.
    • Understanding the genetic and environmental influences on IgE levels is crucial for allergy research.

    Purpose of the Study:

    • To investigate the concordance of serum IgE levels in adult monozygous (identical) and dizygous (fraternal) twin pairs.
    • To explore the phenotypic expression of genotypes related to serum IgE levels.

    Main Methods:

    • Serum IgE levels were measured in 76 monozygous and 81 dizygous like-sexed twin pairs.
    • Participants were adults residing in the Helsinki area.

    Main Results:

    • Monozgous twin pairs exhibited frequent concordance for elevated serum IgE levels.

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  • Significant discordance was observed in some monozygous pairs, indicating variable phenotypic expression.

    • Conclusions:

    • Genetic factors play a role in determining serum IgE levels.
    • Environmental factors or epigenetic modifications likely contribute to the wide range of phenotypic expression observed, even in genetically identical twins.