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Related Experiment Videos

Sydenham chorea: an update

P A Nausieda, B J Grossman, W C Koller

    Neurology
    |March 1, 1980
    PubMed
    Summary

    Sydenham chorea cases dramatically declined between 1951-1976, primarily affecting children. While familial incidence was high, recurrence rates for Sydenham chorea were lower than previously reported.

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    Area of Science:

    • Neurology
    • Pediatrics
    • Epidemiology

    Background:

    • Sydenham chorea, a neurological disorder often linked to rheumatic fever, has seen evolving epidemiological patterns.
    • Understanding its changing characteristics is crucial for diagnosis and management.

    Purpose of the Study:

    • To document potential shifts in the clinical and epidemiological features of Sydenham chorea.
    • To analyze trends in Sydenham chorea incidence and presentation over a 26-year period.

    Main Methods:

    • Retrospective review of medical records for 240 patients diagnosed with Sydenham chorea.
    • Data collection spanned from 1951 to 1976, focusing on demographics, clinical presentation, and family history.

    Main Results:

    • A significant decline in Sydenham chorea cases was observed during the study period.
    • The disorder predominantly affected children, with a female predominance noted after age 10.
    • High familial incidence of both chorea and rheumatic fever was recorded; generalized chorea was most common, and recurrence rates were lower than previously documented.

    Conclusions:

    • Sydenham chorea incidence decreased substantially between 1951 and 1976.
    • Clinical presentation and recurrence patterns may be evolving, necessitating ongoing surveillance.

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