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Genetic influence on serum igd levels

S K Lee, J D Metrakos, K R Tanaka

    Pediatric Research
    |January 1, 1980
    PubMed
    Summary
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    Genetic factors significantly influence serum immunoglobulin D (IgD) levels, similar to immunoglobulin E (IgE). This study highlights a strong hereditary component for both IgD and IgE, impacting their serum concentrations.

    Area of Science:

    • Immunogenetics
    • Human Genetics
    • Molecular Immunology

    Background:

    • Serum immunoglobulin D (IgD) and immunoglobulin E (IgE) levels are crucial biomarkers in immune system function.
    • Understanding the determinants of serum IgD levels is essential for immunological research.
    • Previous studies suggested a genetic influence on serum IgE levels.

    Purpose of the Study:

    • To investigate the genetic and environmental factors influencing serum IgD levels.
    • To compare the genetic heritability of serum IgD with that of serum IgE.
    • To determine the degree of genetic control over serum IgD concentrations.

    Main Methods:

    • Studied 23 nonallergic twin pairs: 16 monozygotic (Mz) and 7 dizygotic (Dz).
    • Measured total serum IgD and IgE using a sensitive paper disc solid phase radioimmunoassay.

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  • Analyzed intrapair variance and calculated heritability and intraclass correlation coefficients.

    • Main Results:

    • Significantly lower intrapair variance for both serum IgD and IgE in Mz twins compared to Dz twins (P < 0.05).
    • Calculated heritability estimates: 0.759 for IgD and 0.697 for IgE.
    • High intraclass correlation coefficients for IgD (0.9370) and IgE (0.8602) in Mz twins (P < 0.001).

    Conclusions:

    • Serum IgD levels are significantly influenced by genetic factors, to a similar extent as serum IgE levels.
    • The number of genetic loci controlling serum IgD may be similar to or fewer than those for serum IgE.
    • Findings confirm a substantial genetic contribution to the variation in serum IgD concentrations.