[Effect of an adrenoreceptor block on ovarian function and hypophyseal gonadotropic function in rats]

Experiments were conducted on rats. Sexual cycle, the state of the sexual system, and the gonadotropic activity of the hypophysis were studied in chronic administration of phentholamine and obsidan. Sexual cycle was found to be disturbed in 60% of rats given phentholamine and in 25% of animals to which obsidan was administered. There was no change in weight of the ovaries or of the uteri in rats treated with adrenoblockers. At the same time the height of the uterine epithelium was diminished, and also a distinct elevation of gonadotropin activity of the hypophysis was seln. It is suggested that chronic administration of adrenoblockers was accompanied by inhibition of gonadotropins secretion from the hypophysis; reduction of the hormonal function of the ovaries ensued.