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Transient elevations in serum alkaline phosphatase were observed in infants. This condition, potentially linked to infection, resolves within weeks and may be asymptomatic, preventing unnecessary diagnostic tests.
Area of Science:
- Pediatrics
- Biochemistry
- Clinical Medicine
Background:
- Transient elevations in serum alkaline phosphatase (SALP) can occur in infants.
- Understanding the etiology and clinical course of SALP variations is crucial for accurate diagnosis.
Observation:
- Six infants presented with striking, transient increases in serum alkaline phosphatase.
- Isoenzyme analysis in three infants revealed elevated activity in both bone and liver fractions.
Findings:
- The observed SALP elevations typically lasted around 11 weeks, peaking at the 6th week.
- The exact cause remains unknown, though an infectious etiology is considered.
- This condition may be common but often presents without obvious symptoms.
Implications:
- Awareness of this transient SALP elevation is vital to prevent unnecessary diagnostic workups in infants.
- Further research into the infectious causes of elevated alkaline phosphatase in pediatric populations is warranted.
Abstract:
Striking transient increases in serum alkaline phosphatase in 6 infants are reported. Isoenzymes were studied in 3 infants and increased activity was found in bone as well as in liver fractions. Repeated serum determinations demonstrated a duration of about 11 weeks with a peak serum value in the 6th week. The etiology is unknown but an infectious cause is discussed. The condition may be rather frequent but gives no obvious symptoms. It is important to know this condition to avoid unnecessary diagnostic procedures.