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Psychological functioning after halothane or enflurane anesthesia

L H Storms, A H Stark, R K Calverley

    Anesthesia and Analgesia
    |April 1, 1980
    PubMed
    Summary
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    General anesthetics halothane and enflurane had minimal impact on cognitive and motor skills in young adults. However, halothane caused more temporary symptoms like dizziness and memory issues compared to enflurane.

    Area of Science:

    • Anesthesiology
    • Neuroscience
    • Psychology

    Background:

    • General anesthetics are widely used in medical procedures.
    • Understanding the short-term cognitive and psychological effects of anesthetics is crucial for patient safety.
    • Halothane and enflurane are common volatile anesthetic agents.

    Purpose of the Study:

    • To evaluate the effects of halothane and enflurane anesthesia on intellectual function, visual-motor coordination, and personality characteristics in young adults.
    • To compare the incidence and duration of post-anesthetic symptoms between halothane and enflurane.

    Main Methods:

    • Young volunteer subjects received either halothane or enflurane anesthesia without surgery.
    • Control subjects were unanesthetized.
    • Cognitive function, visual-motor coordination, and personality were assessed before, 2 days after, and 2 weeks after anesthesia.

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  • Symptom checklists were completed at the same intervals.

    • Main Results:

    • Anesthesia did not significantly alter intellectual function, visual-motor coordination, or personality characteristics in most subjects.
    • Both anesthetics caused temporary symptoms lasting up to 2 days post-administration.
    • Halothane was associated with a greater degree of malaise, including memory difficulties, concentration problems, dizziness, and slowed performance, compared to enflurane.
    • These halothane-induced symptoms resolved by the 2-week follow-up.

    Conclusions:

    • Halothane and enflurane appear to have minimal lasting effects on cognitive and psychomotor performance in young adults.
    • Halothane is associated with more pronounced, albeit temporary, post-anesthetic symptoms than enflurane.
    • Further research may explore long-term effects or effects in different populations.