[Nonspecific effect of pertussis vaccine on the immunologic reactivity of mice]

In experiments on mice of different strains the nonspecific action of pertussis vaccine on the accumulation of antibody-forming cells in the spleen in response to SRBC injection has been studied. Pertussis vaccine can enhance and suppress humoral response to an unrelated antigen. The character of the effect is determined by the dose of the vaccine, the interval between the injection of the preparation and SRBC, as well as by the differences between various strains of mice. The suppression phase was shown to change for the phase of nonspecific enhancement of immune response to an unrelated antigen in vaccinated mice.