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Updated: Aug 18, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

[Detection of complement-binding immune complexes by means of 51Cr-labeled indicator cells--a new radioimmunoassay

A Varga, P Stosiek, M Kasper

    Klinische Wochenschrift
    |May 2, 1980
    PubMed

    A new radioimmunoassay for the detection of complement-binding immune complexes is described. The method is based on the ability of the complexes to bind added guinea pig complement (Clq-Component) so that is not available for lysis of 51Cr-labeled chicken red blood cells in a haemolytic system. Sera from 45 patients with malignant tumours, 20 patients with nonmalignant diseases were studied for the presence of circulating immune complexes. The complement-binding capacity of the sera of patients with significantly greater than that of control sera.

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